Definition
Desistance Rate
The percentage of patients who stop taking a medication, often due to side effects or cost. GLP-1 desistance rates in standard protocols run 50–70%.
From the episode “Peptides, and the Future of Human Performance”Hear it on the podcast1 episode
Learn the language of AI-native founders
Every week: the new terms, tools, and workflows founders are using, straight from the podcast.
Related terms in Health & Science
Cortisol spikeThe stress hormone response repeated alarms may trigger. The mechanism behind the case against serial snoozing.Data vs. Information (Healthcare)Raw clinical data — labs, notes, images, wearable readings — becomes information only when it is integrated, structured, and interpreted in context. Most healthcare systems generate enormous amounts of data; very few generate actionable information. The Mercatus/Diagnostic MD architectural thesis: the value is not in capturing more data but in transforming fragmented data into structured, visual intelligence that a specialist can act on.De-identificationStripping identifiers from health data so it can be shared. The thing TripleBlind's approach was designed to make unnecessary.Default mode networkThe brain network associated with self-referential narrative, the inner monologue, and judgment. fMRI work shows psychedelics temporarily quiet it.Digital therapeuticA software-driven, evidence-based intervention used to prevent or manage a medical condition.DLE (Direct Lithium Extraction)Technology for pulling lithium directly from brines and geothermal waters rather than traditional evaporation ponds.DoomscrollingCompulsively consuming negative or low-value feeds.Dopamine DevotionDr. Dhruva's term for delaying gratification while remaining open to pleasure - choosing mission-aligned action first rather than suppressing desire entirely.