Framework
The Precision Dosing Model
Standard GLP-1 protocols escalate doses on a fixed schedule regardless of individual response. Dr. Ellis argues this is backwards. The goal is to find the lowest dose that suppresses appetite just enough to create a 500–750 calorie deficit — not to eliminate hunger entirely. Think dimmer switch, not on/off toggle.
How it works
- 1Losing at most one pound per week is the target zone
- 2Losing muscle at a 2:1 ratio to fat is the most common and overlooked failure mode
- 3High doses increase cost, increase side effects, and increase desistance rates
Hear it on the podcast
Peptides, and the Future of Human PerformanceListen to the episodeMore from this episode
The Appetite-as-Physiology FrameworkWillpower is not a weight loss strategy. Dr. Ellis compares appetite suppression to sleep deprivation. You can fight it for a day or two, but biological drives increase in intensity until they become inevitable. The solution is not discipline. It is solving the physiologic problem.The Nutrition Hierarchy on GLP-1sBecause appetite is suppressed, what you eat first matters enormously. If you fill up on carbs, you will never reach protein and plants.The Cost-Convenience-Quality TriangleYou only get two. Cheap and convenient equals low quality. Convenient and high quality equals expensive. Inexpensive and high quality means you are cooking it yourself. There is no fourth option.Peptides as Information SystemsPeptides are strings of amino acids that act as keys for specific biological locks. Their safety profile is relatively predictable because they bind to one receptor and produce effects that follow logically from what that receptor does. GLP-1 receptor? Suppresses appetite and slows gastric motility. Overdose? Stomach stops working. Predictable. Manageable.The 15% Body Fat Sweet SpotEvolutionary biology has calibrated human attraction toward function, not aesthetics. Studies show 15% body fat consistently ranks as most attractive across populations because it signals strength, capability, and survivability. Single-digit body fat is not optimal health. It is a performance liability.
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